Dr. Ray Bohlin examines the rapidly moving world of genetic engineering from a Christian worldview perspective. He explains that most genetic engineering attempts to make more efficient changes similar to those previously done through selective breeding and other conventional techniques. However, those working in the field need to be aware of the ethical and religious issues that arise in this area of science.
What Is Genetic Engineering?
Our culture teeters on the edge of a steep and dangerous precipice. New technologies will soon allow us to change, radically and permanently, the world in which we live. Indeed, we will hold in our hands the capability of directly and purposefully changing who we are as human beings. The technology I am speaking of is genetic engineering.{1} Ethical and technical questions swirl around discussions of genetic engineering like the wall clouds of the eye of a hurricane. Many in society seem to be bracing themselves for the disappearance of the calm of the eye and the coming of the full force of a powerful and destructive combination of new plants and animals unleashed on an unsuspecting environment, with new and improved humans designed to succeed.
Before your alarm buttons go on overload, let me say that I hope to lend a reassuring voice with a dose of sober realism. Genetic technology will undoubtedly unleash great power to change our world forever, but should it, and will it? In this article I want to explore just a few of the technical and ethical questions we face as a society. The time to discuss these issues is now, while we still have time to think without simply reacting.
The phrase genetic engineering, unfortunately, often conjures up images of macabre experiments resulting in Frankenstein-like monsters and the cold-hearted use of genetic information to create new social classes depending on our genes, as in the 1997 film Gattaca.{2} However, genetic engineering can simply be defined as the manipulation or alteration of the genetic structure of a single cell or organism.
Sometimes the manipulation of an organism’s genome, the totality of all its genes, can simply refer to the project of identifying its complete DNA sequence in order to gain information for future study and potential alteration. The Human Genome Project is therefore, in a sense, a form of genetic engineering because the human genome must be broken up and manipulated in order to gain the desired information.
Ordinarily, genetic engineering refers to the direct addition, deletion, or intentional mutation of an organism’s DNA sequence to produce a desired effect. Knockout experiments in mice seek to determine the effects of eliminating a particular gene from the mouse genome. Recombinant DNA experiments usually take a gene found in one organism and place the gene into another organism. These animals can be of the same or different species.
Sometimes researchers will simply change the DNA sequence in a gene to study what effect the specific change has on the gene or its protein product. All of these alterations fall under the umbrella of genetic engineering. In this broad definition, genetic engineering is neither good nor evil. The nature of the experiments themselves will determine if they are moral or immoral.
Why Are There Genetic Illnesses?
The initial thrust of genetic research is the treatment and potential cure of genetic illnesses. Therefore, we must explore why genetic illnesses occur at all. “Why questions” within science usually occur on two levels and are notoriously difficult. The first level and usually the easier of the two are the scientific. The “why” is best changed to “how.” For our purposes this means, How do genetic illnesses arise? The second, more difficult question asks on a moral basis, Why do genetic illnesses occur?
The answer to the first question, How do genetic illnesses arise?, is simply, mutations. Mutations are mistakes in the DNA sequence. Sometimes a mutation is simply the substitution of one nucleotide for another.
Mutations can also result from a piece of DNA being deleted. This may cause one or more codons to disappear. In cystic fibrosis (CF), codon 508 out of 1,480 is missing, causing one amino acid to be removed from the resulting protein. This causes the severe respiratory and digestive problems of CF patients that are usually lethal before their 30th birthday.
So far, genes for more than 1,200 human disorders have been identified, which are found over all twenty-three pairs of human chromosomes. Some estimate that there may be as many as 3,000 to 4,000 human genetic disorders that are due to defects in a single gene. Most disorders, however, will be due to mutations in a host of genes.
The moral question is perhaps not so difficult in its answer, but in our acceptance of the answer. Mutations exist as a result of the Fall. We know the serpent was cursed, Eve was cursed, and Adam was cursed (Gen. 3:14-19). But Romans 8:18-22 also tells us that all creation was subjected to futility, groans and suffers, and eagerly awaits the revealing of the sons of God so it may be set free from its slavery to corruption. This world is not as God intended.
Asking why someone suffers from a genetic disease is no different than asking why someone was killed in a traffic accident when others walked away. We know our suffering is temporary. We know that God will somehow work it all out for good (Rom. 8:28). But in 2 Corinthians Paul tells us we suffer so we can comfort those who suffer after us (1:4), so other sufferers will know they are not alone (1:6), and, principally, we suffer so we will trust in God and not ourselves (1:9).
Part of the Christian mission has always been to alleviate suffering where possible. While Jesus’ miracles clearly were part of fulfilled prophecy, they were also about relief from suffering. Genetic engineering, while possessing a power that can be used for evil, which we will discuss, also at least has the potential to relieve the suffering from, if not even cure, genetic disease.
Could Changing Genetic Material Produce a Dangerous Superbug?
One concern that many people have about genetic engineering is the possibility of unintentionally creating a superbug or a damaging plant or animal whose destructive nature is only discovered after the fact. After all, our knowledge of the workings of genes and proteins is still growing. We hear constantly how complex everything is. What makes us think we can tinker with this incredible biological reservoir of information without making some incredible blunder from which there is no turning back?
When genetic engineering in bacteria was first discovered and introduced (Recombinant DNA technology), many scientists had this very fear. This was partially the reason for the self-imposed moratorium and four levels of containment in the early 1970s. But geneticists and molecular biologists found that dangerous, unintentional consequences were virtually nonexistent. Enforcement of the guidelines eventually relaxed and soon became outdated and ignored. What this means is that researchers were quite convinced that transferring DNA of known sequence and function into bacterial chromosomes and plasmids did not result in unforeseen consequences. The procedure became routine and straightforward.
This does not mean that someone, somewhere, won’t use biotechnology to produce a superbug intentionally. Certainly this technology can be used to produce even more powerful and resistant agents of biological warfare. Some even speculated that HIV (human immunodeficiency virus), the virus that causes AIDS, was intentionally produced. Though this hypothesis has been successfully refuted, the prospect remains that DNA recombinant technology has opened up a new field that can be used for evil.
However, we must be clear that this is not the fault of the technology itself. It is entirely human to shrink with fear away from things that we don’t understand. The first predictable reaction of tribal societies when faced with modern technology was to cower in fear. Something dreadful was about to descend upon them. Usually this didn’t happen and, with some education and familiarity, fear dissipated. But only human agents alone can make evil choices. Fire will heat our homes and cook our food, but it can also kill indiscriminately in the hands of an arsonist. But fire itself is not evil.
What should concern us more than the advent of biotechnology is the growing popularity of a totally secular and naturalistic worldview. Naturalism contends that humans are just complicated animals. The end result of this assumption is that ethics becomes an exercise in simply determining what works, not what is right.
Biotechnology is powerful, indeed, but we cannot put the genie back in the bottle. Therefore we must engage the discussion as to how this technology can be used to cure disease and not become another snare to degrade and dehumanize people’s lives.
Are We Playing God by Creating Organisms That Never Existed Before?
Unfortunately, the concept of playing God means different things to different people.{3} For some it may have nothing to do with God at all. They are simply expressing awe and wonder at the power that humans can wield over nature.
For some Christians, however, the notion of playing God carries a pietistic view of God’s realm of activity versus that of the human race. In this context, playing God means performing tasks that are reserved for God and God alone. If this is what genetic technology does, then the concerns about playing God are justified. But what is often being reflected in this perspective is that God acts where we are ignorant and it should stay that way.
What is really at stake is fear, fear of what we may learn, fear of what new responsibility this new knowledge will put on our shoulders, and fear that this new knowledge will be used to harm us and not for the common good. The point was made that technology itself is not evil. Any technology can be used to further God’s purposes or hinder them. People make those decisions, not technology.
By the very fact that we are called to be stewards of God’s creation (Gen. 1:26-28), we need to expand our knowledge of what God has made in order to better rule over His creation. Part of being made in God’s image is our creativity. In this sense we “play God” by imitating Him. Our works of art, buildings, management of natural parks, and care for the poor, sick, and disadvantaged all imitate God for the good of His creation.
But we are still creating new creatures that did not exist before. Isn’t God the only Creator in that sense? We seldom realize that we are hard-pressed to find in nature today the ancestors of nearly all the plants and animals we use for food or service. Our current varieties of corn, wheat, flowers, cattle, dogs, horses, etc., bear little resemblance to the original stock in nature. That is because we have selected and manipulated them over the millennia for our own purposes. We have already created animals and plants that never existed before. Genetic technology has greatly increased the specificity and power of our abilities, but the nature of what we can do is the same as before.
If we are to play God in the sense of imitating Him as we apply the truth of being created in His image and in exercising our appointment as stewards over all He has made, then we need to do so with humility and compassion. Our creative abilities should be used to enhance the condition of men and women as we struggle in a fallen world. Genetic technologies can and should be used to help alleviate or even cure the effects of genetic disease.
Is It Wrong to Combine Genes from Different Species?
Have you ever wondered if we should be transferring genes from one species to another at all? Does this in itself violate some ethical principle? One gene does not define a species. Bacteria are composed of thousands of genes and it is estimated that humans possess as many as 100,000 genes. Therefore, transferring one gene from one organism to another does not create a hybrid in the traditional sense. Genes, remember, are composed of DNA. DNA is a molecule; it is not living in and of itself.
If the idea of adding something foreign to an organism is troublesome, just realize that we do this all the time when we take antibiotics, over the counter pain medications, and other synthetic medications. Our bodies would never come across most of these substances in nature.
What is different is that with genetic engineering, we have added something to a cell or organism that will change the composition of that cell or organism, possibly for as long as it lives, and is potentially passed on to future generations. It is reasonable to ask if we have the wisdom even to try to make these kinds of changes. No doubt, genetic technology provides a power never before possessed by human beings: to design intentionally or create a new variety of organism by altering its genetic structure.
Once again, the issues are, Which genes are actually being transferred? and, For what purpose? These questions, asked case by case, should rule our choices, not the inherent legitimacy of genetic engineering itself. Creating crops internally resistant to disease, particularly to help developing countries better feed their people, is a goal worthy of God’s image-bearers.
However, intentionally manipulating the gene of a known pathogenic and deadly bacterium with the expressed intent of creating a biological weapon that is untreatable and incurable is a hideous evil. Kerby Anderson also warns that we need to consider the extent that genetic manipulation may cross over barriers God instituted in the created kinds.{4} If God felt it important to create boundaries of reproduction that his creatures were to stay within, we ought not cross over them ourselves (Gen. 1:11, 12, 21, 24, 25).
It is certainly possible for genetically modified organisms created for agricultural and medical purposes to develop in ways not planned or foreseen. Therefore, it is necessary that proper and extensive tests be performed to assure, as much as possible, that no unnecessary harm will come to the environment or to humans. As vague as this prescription is, it only serves to reinforce the necessity of further education on the part of everyone to ensure that this powerful technology is used responsibly. We simply cannot afford to be ignorant of genetic issues and technologies and expect to contribute to the necessary discussion that lies ahead.
Notes
1. An excellent resource for Christians on this topic is Genetic Engineering: A Christian Response, Timothy J. Demy and Gary P. Stewart, eds. (Grand Rapids, MI: Kregel Publications, 1999)
2. Gattaca, a film by Andrew Niccol, A Jersey Films production, distributed by Columbia Pictures, 1997.
3. Allen D. Verhey, “Playing God,” in Genetic Ethics: Do the Ends Justify the Genes? (Grand Rapids, MI: Eerdmans Publ. Co., 1997), 60-74.
4. J. Kerby Anderson, “The Ethics of Genetic Engineering and Artificial Reproduction,” in Genetic Engineering: A Christian Response, Timothy J. Demy and Gary P. Stewart.
©2000 Probe Ministries
Dr. Ray Bohlin
Raymond G. Bohlin is Vice President of Vision Outreach at Probe Ministries. He is a graduate of the University of Illinois (B.S., zoology), North Texas State University (M.S., population genetics), and the University of Texas at Dallas (M.S., Ph.D., molecular biology). He is the co-author of the book The Natural Limits to Biological Change, served as general editor of Creation, Evolution and Modern Science, co-author of Basic Questions on Genetics, Stem Cell Research and Cloning (The BioBasics Series), and has published numerous journal articles. Dr. Bohlin was named a Research Fellow of the Discovery Institute's Center for the Renewal of Science and Culture in 1997, 2000 and 2012.
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